diff --git a/specifyweb/frontend/js_src/lib/components/DataModel/__tests__/businessRules.test.ts b/specifyweb/frontend/js_src/lib/components/DataModel/__tests__/businessRules.test.ts
index ce4f0f489c8..2e9fdfe988a 100644
--- a/specifyweb/frontend/js_src/lib/components/DataModel/__tests__/businessRules.test.ts
+++ b/specifyweb/frontend/js_src/lib/components/DataModel/__tests__/businessRules.test.ts
@@ -1,4 +1,4 @@
-import { renderHook } from '@testing-library/react';
+import { act, renderHook } from '@testing-library/react';
 
 import { overrideAjax } from '../../../tests/ajax';
 import { mockTime, requireContext } from '../../../tests/helpers';
@@ -9,7 +9,12 @@ import { getResourceApiUrl } from '../resource';
 import { useSaveBlockers } from '../saveBlockers';
 import { schema } from '../schema';
 import { tables } from '../tables';
-import type { Taxon, TaxonTreeDefItem } from '../types';
+import type {
+  CollectionObjectType,
+  Determination,
+  Taxon,
+  TaxonTreeDefItem,
+} from '../types';
 
 mockTime();
 requireContext();
@@ -49,6 +54,28 @@ describe('Borrow Material business rules', () => {
 });
 
 describe('Collection Object business rules', () => {
+  const collectionObjectTypeUrl = getResourceApiUrl('CollectionObjectType', 1);
+  const collectionObjectType: Partial<
+    SerializedResource<CollectionObjectType>
+  > = {
+    id: 1,
+    name: 'Entomology',
+    taxonTreeDef: getResourceApiUrl('Taxon', 1),
+    resource_uri: collectionObjectTypeUrl,
+  };
+  overrideAjax(collectionObjectTypeUrl, collectionObjectType);
+
+  const otherTaxonId = 1;
+  const otherTaxon: Partial<SerializedResource<Taxon>> = {
+    id: otherTaxonId,
+    isAccepted: true,
+    rankId: 10,
+    definition: getResourceApiUrl('TaxonTreeDef', 2),
+    resource_uri: getResourceApiUrl('Taxon', otherTaxonId),
+  };
+
+  overrideAjax(getResourceApiUrl('Taxon', otherTaxonId), otherTaxon);
+
   const collectionObjectlId = 2;
   const collectionObjectUrl = getResourceApiUrl(
     'CollectionObject',
@@ -58,6 +85,13 @@ describe('Collection Object business rules', () => {
   const getBaseCollectionObject = () =>
     new tables.CollectionObject.Resource({
       id: collectionObjectlId,
+      collectionobjecttype: collectionObjectTypeUrl,
+      determinations: [
+        {
+          taxon: getResourceApiUrl('Taxon', otherTaxonId),
+          preferredTaxon: getResourceApiUrl('Taxon', otherTaxonId),
+        } as SerializedResource<Determination>,
+      ],
       resource_uri: collectionObjectUrl,
     });
 
@@ -80,6 +114,25 @@ describe('Collection Object business rules', () => {
 
     expect(collectionObject.get('collectingEvent')).toBeDefined();
   });
+
+  test('Save blocked when CollectionObjectType of a CollectionObject does not have same tree definition as its associated Determination -> taxon', async () => {
+    const collectionObject = getBaseCollectionObject();
+
+    const determination =
+      collectionObject.getDependentResource('determinations')?.models[0];
+
+    const { result } = renderHook(() =>
+      useSaveBlockers(determination, tables.Determination.getField('taxon'))
+    );
+
+    await act(async () => {
+      await determination?.businessRuleManager?.checkField('taxon');
+    });
+
+    expect(result.current[0]).toStrictEqual([
+      'Taxon does not belong to the same tree as this Object Type',
+    ]);
+  });
 });
 
 describe('DNASequence business rules', () => {
diff --git a/specifyweb/frontend/js_src/lib/components/DataModel/businessRuleDefs.ts b/specifyweb/frontend/js_src/lib/components/DataModel/businessRuleDefs.ts
index ec35f8065d4..9f5500a8eb0 100644
--- a/specifyweb/frontend/js_src/lib/components/DataModel/businessRuleDefs.ts
+++ b/specifyweb/frontend/js_src/lib/components/DataModel/businessRuleDefs.ts
@@ -1,3 +1,4 @@
+import { formsText } from '../../localization/forms';
 import { resourcesText } from '../../localization/resources';
 import type { BusinessRuleResult } from './businessRules';
 import type { AnySchema, TableFields } from './helperTypes';
@@ -17,6 +18,7 @@ import type {
   Address,
   BorrowMaterial,
   CollectionObject,
+  CollectionObjectType,
   Determination,
   DNASequence,
   LoanPreparation,
@@ -47,6 +49,7 @@ type MappedBusinessRuleDefs = {
 };
 
 const CURRENT_DETERMINATION_KEY = 'determination-isCurrent';
+const DETERMINATION_TAXON_KEY = 'determination-taxon';
 
 export const businessRuleDefs: MappedBusinessRuleDefs = {
   Address: {
@@ -153,7 +156,7 @@ export const businessRuleDefs: MappedBusinessRuleDefs = {
     fieldChecks: {
       taxon: async (
         determination: SpecifyResource<Determination>
-      ): Promise<BusinessRuleResult> =>
+      ): Promise<BusinessRuleResult | undefined> =>
         determination
           .rgetPromise('taxon', true)
           .then((taxon: SpecifyResource<Taxon> | null) => {
@@ -165,6 +168,40 @@ export const businessRuleDefs: MappedBusinessRuleDefs = {
                 .then(async (accepted) =>
                   accepted === null ? taxon : getLastAccepted(accepted)
                 );
+
+            const collectionObject = determination.collection?.related;
+            if (
+              collectionObject !== undefined &&
+              collectionObject.specifyTable.name === 'CollectionObject'
+            )
+              (collectionObject as SpecifyResource<CollectionObject>)
+                .rgetPromise('collectionObjectType', true)
+                .then((coType: SpecifyResource<CollectionObjectType>) => {
+                  /*
+                   * Have to set save blockers directly here to get this working.
+                   * Since following code has to wait for above rgetPromise to resolve, returning a Promise<BusinessRuleResult> for validation here is too slow and
+                   * does not get captured by business rules.
+                   */
+                  if (
+                    coType.get('taxonTreeDef') ===
+                    (taxon?.get('definition') ?? '')
+                  ) {
+                    setSaveBlockers(
+                      determination,
+                      determination.specifyTable.field.taxon,
+                      [],
+                      DETERMINATION_TAXON_KEY
+                    );
+                  } else {
+                    setSaveBlockers(
+                      determination,
+                      determination.specifyTable.field.taxon,
+                      [formsText.invalidTree()],
+                      DETERMINATION_TAXON_KEY
+                    );
+                  }
+                });
+
             return taxon === null
               ? {
                   isValid: true,
diff --git a/specifyweb/frontend/js_src/lib/localization/forms.ts b/specifyweb/frontend/js_src/lib/localization/forms.ts
index 9134ba47354..74100c1982f 100644
--- a/specifyweb/frontend/js_src/lib/localization/forms.ts
+++ b/specifyweb/frontend/js_src/lib/localization/forms.ts
@@ -1159,4 +1159,7 @@ export const formsText = createDictionary({
     'ru-ru': 'Номер по каталогу Числовой',
     'uk-ua': 'Каталожний номер Числовий',
   },
+  invalidTree: {
+    'en-us': 'Taxon does not belong to the same tree as this Object Type',
+  },
 } as const);