diff --git a/model-engine/model_engine_server/api/tasks_v1.py b/model-engine/model_engine_server/api/tasks_v1.py
index 524f2f462..663b3e0c2 100644
--- a/model-engine/model_engine_server/api/tasks_v1.py
+++ b/model-engine/model_engine_server/api/tasks_v1.py
@@ -18,6 +18,7 @@
 from model_engine_server.core.loggers import logger_name, make_logger
 from model_engine_server.domain.exceptions import (
     EndpointUnsupportedInferenceTypeException,
+    InvalidRequestException,
     ObjectNotAuthorizedException,
     ObjectNotFoundException,
     UpstreamServiceError,
@@ -66,6 +67,11 @@ async def create_async_inference_task(
             status_code=400,
             detail=f"Unsupported inference type: {str(exc)}",
         ) from exc
+    except InvalidRequestException as exc:
+        raise HTTPException(
+            status_code=400,
+            detail=f"Invalid request: {str(exc)}",
+        ) from exc
 
 
 @inference_task_router_v1.get("/async-tasks/{task_id}", response_model=GetAsyncTaskV1Response)
diff --git a/model-engine/model_engine_server/infra/gateways/celery_task_queue_gateway.py b/model-engine/model_engine_server/infra/gateways/celery_task_queue_gateway.py
index 7a8f6911a..676a12743 100644
--- a/model-engine/model_engine_server/infra/gateways/celery_task_queue_gateway.py
+++ b/model-engine/model_engine_server/infra/gateways/celery_task_queue_gateway.py
@@ -1,5 +1,6 @@
 from typing import Any, Dict, List, Optional
 
+import botocore
 from model_engine_server.common.dtos.model_endpoints import BrokerType
 from model_engine_server.common.dtos.tasks import (
     CreateAsyncTaskV1Response,
@@ -9,6 +10,7 @@
 from model_engine_server.core.celery import TaskVisibility, celery_app
 from model_engine_server.core.config import infra_config
 from model_engine_server.core.loggers import logger_name, make_logger
+from model_engine_server.domain.exceptions import InvalidRequestException
 from model_engine_server.domain.gateways.task_queue_gateway import TaskQueueGateway
 
 logger = make_logger(logger_name())
@@ -68,12 +70,16 @@ def send_task(
     ) -> CreateAsyncTaskV1Response:
         celery_dest = self._get_celery_dest()
 
-        res = celery_dest.send_task(
-            name=task_name,
-            args=args,
-            kwargs=kwargs,
-            queue=queue_name,
-        )
+        try:
+            res = celery_dest.send_task(
+                name=task_name,
+                args=args,
+                kwargs=kwargs,
+                queue=queue_name,
+            )
+        except botocore.exceptions.ClientError as e:
+            logger.exception(f"Error sending task to queue {queue_name}: {e}")
+            raise InvalidRequestException(f"Error sending celery task: {e}")
         logger.info(f"Task {res.id} sent to queue {queue_name} from gateway")  # pragma: no cover
         return CreateAsyncTaskV1Response(task_id=res.id)
 
diff --git a/model-engine/tests/integration/inference/test_async_inference.py b/model-engine/tests/integration/inference/test_async_inference.py
index e96164d7a..db9bc9a77 100644
--- a/model-engine/tests/integration/inference/test_async_inference.py
+++ b/model-engine/tests/integration/inference/test_async_inference.py
@@ -4,7 +4,9 @@
 import subprocess
 from functools import lru_cache
 from typing import Any, List, Optional, Tuple
+from unittest.mock import MagicMock
 
+import botocore
 import pytest
 import redis
 import requests
@@ -17,6 +19,7 @@
     TaskStatus,
 )
 from model_engine_server.common.env_vars import CIRCLECI
+from model_engine_server.domain.exceptions import InvalidRequestException
 from model_engine_server.infra.gateways import (
     CeleryTaskQueueGateway,
     LiveAsyncModelEndpointInferenceGateway,
@@ -157,3 +160,24 @@ def test_async_callbacks(
     assert actual_payload == expected_callback_payload
 
     assert callback_stats["last_auth"][callback_version] == expected_credentials
+
+
+def test_async_callbacks_botocore_exception(
+    queue: str,
+):
+    gateway = CeleryTaskQueueGateway(broker_type=BrokerType.SQS)
+
+    mock_dest = MagicMock()
+    mock_dest.send_task = MagicMock(
+        side_effect=botocore.exceptions.ClientError(error_response={}, operation_name="")
+    )
+    mock_get = MagicMock()
+    mock_get.return_value = mock_dest
+    gateway._get_celery_dest = mock_get
+
+    with pytest.raises(InvalidRequestException):
+        gateway.send_task(
+            task_name="test_task",
+            queue_name=queue,
+            args=[1, 2],
+        )
diff --git a/model-engine/tests/unit/api/test_tasks.py b/model-engine/tests/unit/api/test_tasks.py
index f9a0f0620..3d019016c 100644
--- a/model-engine/tests/unit/api/test_tasks.py
+++ b/model-engine/tests/unit/api/test_tasks.py
@@ -4,6 +4,7 @@
 from model_engine_server.common.dtos.tasks import EndpointPredictV1Request
 from model_engine_server.domain.entities import ModelBundle, ModelEndpoint
 from model_engine_server.domain.exceptions import (
+    InvalidRequestException,
     ObjectNotAuthorizedException,
     ObjectNotFoundException,
     UpstreamServiceError,
@@ -104,6 +105,43 @@ def test_create_async_task_raises_404_not_found(
     assert response.status_code == 404
 
 
+def test_create_async_task_raises_400_invalid_requests(
+    model_bundle_1_v1: Tuple[ModelBundle, Any],
+    model_endpoint_1: Tuple[ModelEndpoint, Any],
+    endpoint_predict_request_1: Tuple[EndpointPredictV1Request, Dict[str, Any]],
+    test_api_key: str,
+    get_test_client_wrapper,
+):
+    assert model_endpoint_1[0].infra_state is not None
+    client = get_test_client_wrapper(
+        fake_docker_repository_image_always_exists=True,
+        fake_model_bundle_repository_contents={
+            model_bundle_1_v1[0].id: model_bundle_1_v1[0],
+        },
+        fake_model_endpoint_record_repository_contents={
+            model_endpoint_1[0].record.id: model_endpoint_1[0].record,
+        },
+        fake_model_endpoint_infra_gateway_contents={
+            model_endpoint_1[0].infra_state.deployment_name: model_endpoint_1[0].infra_state,
+        },
+        fake_batch_job_record_repository_contents={},
+        fake_batch_job_progress_gateway_contents={},
+        fake_docker_image_batch_job_bundle_repository_contents={},
+    )
+    mock_use_case = MagicMock()
+    mock_use_case.return_value.execute = MagicMock(side_effect=InvalidRequestException)
+    with patch(
+        "model_engine_server.api.tasks_v1.CreateAsyncInferenceTaskV1UseCase",
+        mock_use_case,
+    ):
+        response = client.post(
+            "/v1/async-tasks?model_endpoint_id=invalid_model_endpoint_id",
+            auth=(test_api_key, ""),
+            json=endpoint_predict_request_1[1],
+        )
+        assert response.status_code == 400
+
+
 def test_get_async_task_success(
     model_bundle_1_v1: Tuple[ModelBundle, Any],
     model_endpoint_1: Tuple[ModelEndpoint, Any],