diff --git a/src/coreclr/vm/codeman.cpp b/src/coreclr/vm/codeman.cpp
index d7af1a7af7041f..005f0dad2226ca 100644
--- a/src/coreclr/vm/codeman.cpp
+++ b/src/coreclr/vm/codeman.cpp
@@ -1539,7 +1539,15 @@ void EEJitManager::SetCpuInfo()
 
     // x86-64-v3
 
-    if (((cpuFeatures & XArchIntrinsicConstants_Avx) != 0) && CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_EnableAVX))
+    bool enableAVX = ((cpuFeatures & XArchIntrinsicConstants_Avx) != 0) && CLRConfig::GetConfigValue(CLRConfig::EXTERNAL_EnableAVX);
+
+#if defined(FEATURE_INTERPRETER)
+    // The interpreter only supports 128-bit vectors, so don't enable AVX. The ISA
+    // dependency normalization below then removes the dependent AVX2/AVX512.
+    enableAVX = enableAVX && !interpreterOnly;
+#endif
+
+    if (enableAVX)
     {
         CPUCompileFlags.Set(InstructionSet_AVX);
     }
@@ -1883,6 +1891,15 @@ void EEJitManager::SetCpuInfo()
         preferredVectorBitWidth = 256;
     }
 
+#if defined(FEATURE_INTERPRETER)
+    if (interpreterOnly && (preferredVectorBitWidth > 128))
+    {
+        // Limit the preferred vector width so the Vector256/Vector512 marker ISAs
+        // set below are not reported after AVX was left disabled above.
+        preferredVectorBitWidth = 128;
+    }
+#endif
+
     if (preferredVectorBitWidth >= 512)
     {
         CPUCompileFlags.Set(InstructionSet_Vector512);