diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 4de29857494251..c9711aff2d5bfb 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -183,10 +183,8 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime\tests\System.IO.FileSystem.Tests\DisabledFileLockingTests\System.IO.FileSystem.DisabledFileLocking.Tests.csproj" />
   </ItemGroup>
 
-  <!-- https://github.com/dotnet/runtime/issues/125495 - These tests are disabled on browser/CoreCLR because of crashes and test failures. -->
+  <!-- https://github.com/dotnet/runtime/issues/125495 - Some test suites are disabled on browser/CoreCLR (e.g., long running suites). -->
   <ItemGroup Condition="'$(TargetOS)' == 'browser' and '$(RuntimeFlavor)' == 'CoreCLR' and '$(RunDisabledWasmTests)' != 'true'">
-    <!-- test failures -->
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Formats.Nrbf\tests\System.Formats.Nrbf.Tests.csproj" />
     <!-- long running suites -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Linq\tests\System.Linq.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Memory\tests\System.Memory.Tests.csproj" />
diff --git a/src/mono/browser/build/BrowserWasmApp.CoreCLR.targets b/src/mono/browser/build/BrowserWasmApp.CoreCLR.targets
index e94f759abc4f69..52dece99895f9c 100644
--- a/src/mono/browser/build/BrowserWasmApp.CoreCLR.targets
+++ b/src/mono/browser/build/BrowserWasmApp.CoreCLR.targets
@@ -178,6 +178,53 @@
                      '$(WasmBuildingForNestedPublish)' != 'true' and
                      '$(UsingBrowserRuntimeWorkload)' != 'true'" />
 
+  <!-- ======================== Prefer app-local assemblies over runtime-pack copies ========================
+
+    For a self-contained browser-wasm app, @(ReferenceCopyLocalPaths) can contain two copies of the
+    same assembly: the runtime-pack copy (under $(MicrosoftNetCoreAppRuntimePackDir)) and an app-local
+    copy referenced out-of-band at a different version. ComputeWasmBuildAssets dedupes the webcil bundle
+    candidates by relative path (first-wins, version-blind), so the runtime-pack copy can shadow the
+    app-local one in _framework. The canonical case is System.Runtime.Serialization.Formatters: the
+    shared framework ships a non-functional 8.1.0.0 stub while the app references the functional 11.0.0.0
+    build, so an Assembly.Load for 11.0.0.0 then fails with FileNotFoundException.
+
+    Resolve it the way a self-contained app loads assemblies (copy-local wins): drop runtime-pack copies
+    shadowed by a same-named app-local copy before the candidates are gathered. Apps without an app-local
+    copy of a framework assembly are unaffected.
+
+    DependsOnTargets=ResolveReferences guarantees @(ReferenceCopyLocalPaths) is populated before we prune;
+    _GatherWasmFilesToBuild (unlike _ComputeWasmBuildCandidates) does not pull it in on its own.
+  -->
+  <Target Name="_CoreCLRPreferAppLocalAssembliesOverRuntimePack"
+          BeforeTargets="_ComputeWasmBuildCandidates;_GatherWasmFilesToBuild"
+          DependsOnTargets="ResolveReferences"
+          Condition="'$(IsBrowserWasmProject)' == 'true'">
+    <PropertyGroup>
+      <!-- Resolve the runtime pack dir the same way the WebAssembly SDK does (Browser.targets): prefer
+           the property, fall back to the ResolvedRuntimePack metadata (WBT/Helix-created projects leave
+           the property empty). Normalize once (full path + trailing slash) so the StartsWith checks
+           below reliably match %(FullPath), which uses native separators. -->
+      <_CoreCLRRuntimePackDir>$(MicrosoftNetCoreAppRuntimePackDir)</_CoreCLRRuntimePackDir>
+      <_CoreCLRRuntimePackDir Condition="'$(_CoreCLRRuntimePackDir)' == ''">%(ResolvedRuntimePack.PackageDirectory)</_CoreCLRRuntimePackDir>
+      <_CoreCLRRuntimePackDir Condition="'$(_CoreCLRRuntimePackDir)' != ''">$([MSBuild]::NormalizeDirectory('$(_CoreCLRRuntimePackDir)'))</_CoreCLRRuntimePackDir>
+    </PropertyGroup>
+    <ItemGroup Condition="'$(_CoreCLRRuntimePackDir)' != ''">
+      <!-- App-local (non-runtime-pack) managed assemblies copied next to the app. -->
+      <_CoreCLRAppLocalAssembly Include="@(ReferenceCopyLocalPaths)"
+                                Condition="'%(Extension)' == '.dll' and !$([System.String]::Copy('%(FullPath)').StartsWith('$(_CoreCLRRuntimePackDir)'))" />
+    </ItemGroup>
+    <PropertyGroup>
+      <_CoreCLRAppLocalAssemblyNames>;@(_CoreCLRAppLocalAssembly->'%(FileName)%(Extension)');</_CoreCLRAppLocalAssemblyNames>
+    </PropertyGroup>
+    <ItemGroup Condition="'$(_CoreCLRRuntimePackDir)' != ''">
+      <!-- Drop runtime-pack copies shadowed by a same-named app-local assembly. -->
+      <ReferenceCopyLocalPaths Remove="@(ReferenceCopyLocalPaths)"
+                               Condition="'%(Extension)' == '.dll'
+                                          and $([System.String]::Copy('%(FullPath)').StartsWith('$(_CoreCLRRuntimePackDir)'))
+                                          and $(_CoreCLRAppLocalAssemblyNames.Contains(';%(FileName)%(Extension);'))" />
+    </ItemGroup>
+  </Target>
+
   <!-- ======================== Core Orchestrator ======================== -->
 
   <PropertyGroup>