diff --git a/src/coreclr/jit/gentree.cpp b/src/coreclr/jit/gentree.cpp
index 5a65ddcadf0943..4f1f0395a7fc12 100644
--- a/src/coreclr/jit/gentree.cpp
+++ b/src/coreclr/jit/gentree.cpp
@@ -33828,7 +33828,17 @@ GenTree* Compiler::gtFoldExprHWIntrinsic(GenTreeHWIntrinsic* tree)
                     case FloatComparisonMode::OrderedFalseNonSignaling:
                     case FloatComparisonMode::OrderedFalseSignaling:
                     {
-                        resultNode = gtNewZeroConNode(retType);
+                        if (ni == NI_AVX_CompareScalar)
+                        {
+                            // CompareScalar preserves upper elements from op1,
+                            // so we can't fold to a full zero vector
+                            break;
+                        }
+                        // CompareMask returns TYP_MASK which gtNewZeroConNode doesn't handle,
+                        // so use the SIMD vector type instead; the mask conversion at the end
+                        // of this function will wrap it with CvtVectorToMask
+                        resultNode = gtNewZeroConNode(varTypeIsMask(retType) ? getSIMDTypeForSize(simdSize)
+                                                                            : retType);
                         resultNode = gtWrapWithSideEffects(resultNode, tree, GTF_ALL_EFFECT);
                         break;
                     }
@@ -33836,7 +33846,17 @@ GenTree* Compiler::gtFoldExprHWIntrinsic(GenTreeHWIntrinsic* tree)
                     case FloatComparisonMode::UnorderedTrueNonSignaling:
                     case FloatComparisonMode::UnorderedTrueSignaling:
                     {
-                        resultNode = gtNewAllBitsSetConNode(retType);
+                        if (ni == NI_AVX_CompareScalar)
+                        {
+                            // CompareScalar preserves upper elements from op1,
+                            // so we can't fold to a full AllBitsSet vector
+                            break;
+                        }
+                        // CompareMask returns TYP_MASK which gtNewAllBitsSetConNode doesn't handle,
+                        // so use the SIMD vector type instead; the mask conversion at the end
+                        // of this function will wrap it with CvtVectorToMask
+                        resultNode = gtNewAllBitsSetConNode(varTypeIsMask(retType) ? getSIMDTypeForSize(simdSize)
+                                                                                  : retType);
                         resultNode = gtWrapWithSideEffects(resultNode, tree, GTF_ALL_EFFECT);
                         break;
                     }
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_125160/Runtime_125160.cs b/src/tests/JIT/Regression/JitBlue/Runtime_125160/Runtime_125160.cs
new file mode 100644
index 00000000000000..aace13ceda7813
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_125160/Runtime_125160.cs
@@ -0,0 +1,69 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+using System;
+using System.Runtime.CompilerServices;
+using System.Runtime.Intrinsics;
+using System.Runtime.Intrinsics.X86;
+using Xunit;
+
+public class Runtime_125160
+{
+    [ConditionalFact(typeof(Avx), nameof(Avx.IsSupported))]
+    public static void TestEntryPoint()
+    {
+        Assert.Equal(Vector128.Create(0f, 1f, 1f, 1f), CompareFalseFloat(Vector128<float>.One, Vector128<float>.Zero));
+        Assert.Equal(Vector128.Create(0d, 1d), CompareFalseDouble(Vector128<double>.One, Vector128<double>.Zero));
+
+        Vector128<float> trueFloat = CompareTrueFloat(Vector128<float>.One, Vector128<float>.Zero);
+        Assert.Equal(BitConverter.UInt32BitsToSingle(0xFFFFFFFF), trueFloat.GetElement(0));
+        Assert.Equal(1f, trueFloat.GetElement(1));
+        Assert.Equal(1f, trueFloat.GetElement(2));
+        Assert.Equal(1f, trueFloat.GetElement(3));
+
+        Vector128<double> trueDouble = CompareTrueDouble(Vector128<double>.One, Vector128<double>.Zero);
+        Assert.Equal(BitConverter.UInt64BitsToDouble(0xFFFFFFFFFFFFFFFF), trueDouble.GetElement(0));
+        Assert.Equal(1d, trueDouble.GetElement(1));
+    }
+
+    [ConditionalFact(typeof(Avx512F), nameof(Avx512F.IsSupported))]
+    public static void TestCompareMask()
+    {
+        Assert.Equal(Vector512<float>.Zero, CompareMaskFalseFloat(Vector512<float>.One, Vector512<float>.Zero));
+        Assert.Equal(Vector512<double>.Zero, CompareMaskFalseDouble(Vector512<double>.One, Vector512<double>.Zero));
+        Assert.Equal(Vector512<float>.AllBitsSet, CompareMaskTrueFloat(Vector512<float>.One, Vector512<float>.Zero));
+        Assert.Equal(Vector512<double>.AllBitsSet, CompareMaskTrueDouble(Vector512<double>.One, Vector512<double>.Zero));
+    }
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector128<float> CompareFalseFloat(Vector128<float> x, Vector128<float> y)
+        => Avx.CompareScalar(x, y, FloatComparisonMode.OrderedFalseSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector128<double> CompareFalseDouble(Vector128<double> x, Vector128<double> y)
+        => Avx.CompareScalar(x, y, FloatComparisonMode.OrderedFalseNonSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector128<float> CompareTrueFloat(Vector128<float> x, Vector128<float> y)
+        => Avx.CompareScalar(x, y, FloatComparisonMode.UnorderedTrueSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector128<double> CompareTrueDouble(Vector128<double> x, Vector128<double> y)
+        => Avx.CompareScalar(x, y, FloatComparisonMode.UnorderedTrueNonSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector512<float> CompareMaskFalseFloat(Vector512<float> x, Vector512<float> y)
+        => Avx512F.Compare(x, y, FloatComparisonMode.OrderedFalseSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector512<double> CompareMaskFalseDouble(Vector512<double> x, Vector512<double> y)
+        => Avx512F.Compare(x, y, FloatComparisonMode.OrderedFalseNonSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector512<float> CompareMaskTrueFloat(Vector512<float> x, Vector512<float> y)
+        => Avx512F.Compare(x, y, FloatComparisonMode.UnorderedTrueSignaling);
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    static Vector512<double> CompareMaskTrueDouble(Vector512<double> x, Vector512<double> y)
+        => Avx512F.Compare(x, y, FloatComparisonMode.UnorderedTrueNonSignaling);
+}
diff --git a/src/tests/JIT/Regression/Regression_ro_2.csproj b/src/tests/JIT/Regression/Regression_ro_2.csproj
index 9920332e7f1c0f..5c62eb98295716 100644
--- a/src/tests/JIT/Regression/Regression_ro_2.csproj
+++ b/src/tests/JIT/Regression/Regression_ro_2.csproj
@@ -89,6 +89,7 @@
     <Compile Include="JitBlue\Runtime_123790\Runtime_123790.cs" />
     <Compile Include="JitBlue\Runtime_124082\Runtime_124082.cs" />
     <Compile Include="JitBlue\Runtime_125041\Runtime_125041.cs" />
+    <Compile Include="JitBlue\Runtime_125160\Runtime_125160.cs" />
   </ItemGroup>
   <Import Project="$(TestSourceDir)MergedTestRunner.targets" />
 </Project>