diff --git a/monai/bundle/config_parser.py b/monai/bundle/config_parser.py
index 791759fd65..b4ffc853bb 100644
--- a/monai/bundle/config_parser.py
+++ b/monai/bundle/config_parser.py
@@ -178,11 +178,27 @@ def get(self, id: str = "", default: Optional[Any] = None):
 
     def set(self, config: Any, id: str = ""):
         """
-        Set config by ``id``. See also :py:meth:`__setitem__`.
+        Set config by ``id``.
+
+        Args:
+            config: config to set at location ``id``.
+            id: id to specify the expected position. See also :py:meth:`__setitem__`.
 
         """
         self[id] = config
 
+    def update(self, pairs: Dict[str, Any]):
+        """
+        Set the ``id`` and the corresponding config content in pairs, see also :py:meth:`__setitem__`.
+        For example, ``parser.update({"train#epoch": 100, "train#lr": 0.02})``
+
+        Args:
+            pairs: dictionary of `id` and config pairs.
+
+        """
+        for k, v in pairs.items():
+            self[k] = v
+
     def __contains__(self, id: Union[str, int]) -> bool:
         """
         Returns True if `id` is stored in this configuration.
diff --git a/monai/bundle/scripts.py b/monai/bundle/scripts.py
index 3f9241be09..c01498bb09 100644
--- a/monai/bundle/scripts.py
+++ b/monai/bundle/scripts.py
@@ -372,8 +372,7 @@ def run(
         parser.read_meta(f=meta_file_)
 
     # the rest key-values in the _args are to override config content
-    for k, v in _args.items():
-        parser[k] = v
+    parser.update(pairs=_args)
 
     # resolve and execute the specified runner expressions in the config, return the results
     return [parser.get_parsed_content(i, lazy=True, eval_expr=True, instantiate=True) for i in ensure_tuple(runner_id_)]
diff --git a/tests/test_config_parser.py b/tests/test_config_parser.py
index 81e96d4095..f991b3f5f5 100644
--- a/tests/test_config_parser.py
+++ b/tests/test_config_parser.py
@@ -104,6 +104,8 @@ def test_config_content(self):
         # test nested ids
         parser["dataset#_target_"] = "Dataset"
         self.assertEqual(parser["dataset#_target_"], "Dataset")
+        parser.update({"dataset#_target_1": "Dataset1"})
+        self.assertEqual(parser["dataset#_target_1"], "Dataset1")
         # test int id
         parser.set(["test1", "test2", "test3"])
         parser[1] = "test4"