diff --git a/docs/source/inferers.rst b/docs/source/inferers.rst
index 544e695d2e..e358e603bd 100644
--- a/docs/source/inferers.rst
+++ b/docs/source/inferers.rst
@@ -30,3 +30,9 @@ Inferers
 .. autoclass:: SlidingWindowInferer
     :members:
     :special-members: __call__
+
+`SaliencyInferer`
+~~~~~~~~~~~~~~~~~
+.. autoclass:: SaliencyInferer
+    :members:
+    :special-members: __call__
diff --git a/monai/inferers/__init__.py b/monai/inferers/__init__.py
index 1cdea77b0f..030344728d 100644
--- a/monai/inferers/__init__.py
+++ b/monai/inferers/__init__.py
@@ -9,5 +9,5 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-from .inferer import Inferer, SimpleInferer, SlidingWindowInferer
+from .inferer import Inferer, SaliencyInferer, SimpleInferer, SlidingWindowInferer
 from .utils import sliding_window_inference
diff --git a/monai/inferers/inferer.py b/monai/inferers/inferer.py
index b17afb4e1d..ecb2c2c178 100644
--- a/monai/inferers/inferer.py
+++ b/monai/inferers/inferer.py
@@ -10,14 +10,16 @@
 # limitations under the License.
 
 from abc import ABC, abstractmethod
-from typing import Any, Callable, Sequence, Union
+from typing import Any, Callable, Optional, Sequence, Union
 
 import torch
+import torch.nn as nn
 
 from monai.inferers.utils import sliding_window_inference
 from monai.utils import BlendMode, PytorchPadMode
+from monai.visualize import CAM, GradCAM, GradCAMpp
 
-__all__ = ["Inferer", "SimpleInferer", "SlidingWindowInferer"]
+__all__ = ["Inferer", "SimpleInferer", "SlidingWindowInferer", "SaliencyInferer"]
 
 
 class Inferer(ABC):
@@ -190,3 +192,54 @@ def __call__(
             *args,
             **kwargs,
         )
+
+
+class SaliencyInferer(Inferer):
+    """
+    SaliencyInferer is inference with activation maps.
+
+    Args:
+        cam_name: expected CAM method name, should be: "CAM", "GradCAM" or "GradCAMpp".
+        target_layers: name of the model layer to generate the feature map.
+        class_idx: index of the class to be visualized. if None, default to argmax(logits).
+        args: other optional args to be passed to the `__init__` of cam.
+        kwargs: other optional keyword args to be passed to `__init__` of cam.
+
+    """
+
+    def __init__(self, cam_name: str, target_layers: str, class_idx: Optional[int] = None, *args, **kwargs) -> None:
+        Inferer.__init__(self)
+        if cam_name.lower() not in ("cam", "gradcam", "gradcampp"):
+            raise ValueError("cam_name should be: 'CAM', 'GradCAM' or 'GradCAMpp'.")
+        self.cam_name = cam_name.lower()
+        self.target_layers = target_layers
+        self.class_idx = class_idx
+        self.args = args
+        self.kwargs = kwargs
+
+    def __call__(  # type: ignore
+        self,
+        inputs: torch.Tensor,
+        network: nn.Module,
+        *args: Any,
+        **kwargs: Any,
+    ):
+        """Unified callable function API of Inferers.
+
+        Args:
+            inputs: model input data for inference.
+            network: target model to execute inference.
+                supports callables such as ``lambda x: my_torch_model(x, additional_config)``
+            args: other optional args to be passed to the `__call__` of cam.
+            kwargs: other optional keyword args to be passed to `__call__` of cam.
+
+        """
+        cam: Union[CAM, GradCAM, GradCAMpp]
+        if self.cam_name == "cam":
+            cam = CAM(network, self.target_layers, *self.args, **self.kwargs)
+        elif self.cam_name == "gradcam":
+            cam = GradCAM(network, self.target_layers, *self.args, **self.kwargs)
+        else:
+            cam = GradCAMpp(network, self.target_layers, *self.args, **self.kwargs)
+
+        return cam(inputs, self.class_idx, *args, **kwargs)
diff --git a/tests/test_sailency_inferer.py b/tests/test_sailency_inferer.py
new file mode 100644
index 0000000000..276bc7816c
--- /dev/null
+++ b/tests/test_sailency_inferer.py
@@ -0,0 +1,52 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import torch
+from parameterized import parameterized
+
+from monai.inferers import SaliencyInferer
+from monai.networks.nets import DenseNet
+from monai.visualize.visualizer import default_upsampler
+
+TEST_CASE_1 = ["CAM"]
+
+TEST_CASE_2 = ["GradCAM"]
+
+TEST_CASE_3 = ["GradCAMpp"]
+
+
+class TestGradientClassActivationMap(unittest.TestCase):
+    @parameterized.expand([TEST_CASE_1, TEST_CASE_2, TEST_CASE_3])
+    def test_shape(self, cam_name):
+        model = DenseNet(
+            spatial_dims=3, in_channels=1, out_channels=3, init_features=2, growth_rate=2, block_config=(6,)
+        )
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        model.to(device)
+        model.eval()
+
+        image = torch.rand((2, 1, 6, 6, 6), device=device)
+        target_layer = "class_layers.relu"
+        fc_layer = "class_layers.out"
+        if cam_name == "CAM":
+            inferer = SaliencyInferer(cam_name, target_layer, None, fc_layer, upsampler=default_upsampler)
+            result = inferer(inputs=image, network=model, layer_idx=-1)
+        else:
+            inferer = SaliencyInferer(cam_name, target_layer, None, upsampler=default_upsampler)
+            result = inferer(image, model, -1, retain_graph=False)
+
+        self.assertTupleEqual(result.shape, (2, 1, 6, 6, 6))
+
+
+if __name__ == "__main__":
+    unittest.main()